Genistein is a natural isoflavone compound extracted from plants such as sophora japonica and kudzu root. It is a light yellow crystalline powder. Our product adopts advanced extraction and purification technology, featuring high purity, stable quality and low impurity content. Genistein is widely applied in dietary supplements, health products, cosmetics and biotech research fields. We can provide different specifications to meet customized requirements for various downstream formulations.
Specification: 98% Appearance: Off-white fine powder Used Part: Sophora japonica fruit Test Method: HPLC Solubility: Practically insoluble in water, soluble in dilute alkali and DMSO, slightly soluble in hot ethanol MOQ: 1 kg Sample: 10‑20 g Packing: 1 kg in aluminum foil bag; 25 kg in fibre drum Delivery: FedEx, DHL, air shipment, sea shipment Certifications: ISO, HACCP, KOSHER, HALAL, BRC Features: Non‑irradiated GMO‑free, TSE/BSE‑free No ETO treatment throughout production, storage and transportation
VistaExtract operates a certified processing facility specializing in Genistein, a high‑purity natural isoflavone phytoestrogen ingredient isolated from Sophora japonica fruit through controlled food‑grade solvent extraction, column chromatography and low‑temperature recrystallization. Our production workflow isolates and standardizes genistein, the primary bioactive isoflavone compound, delivering consistent material for women’s health supplement manufacturers, anti‑aging cosmetic formulators, and nutraceutical developers worldwide.
Why Choose VistaExtract Genistein
Natural Isolated Isoflavone Active — Genistein is a well‑characterized plant‑derived selective estrogen receptor modulator (SERM). Sourced from Sophora japonica fruit, it delivers defined phytoestrogen, antioxidant and tyrosine‑kinase‑inhibiting activity as a single standardized active ingredient. Formulators obtain high‑purity genistein rather than working with variable‑content crude botanical powders, simplifying dosage design and label‑claim compliance.
Gentle Low‑Temperature Purification for Bioactivity Preservation — Our manufacturing applies optimized food‑grade solvent extraction, chromatographic separation and low‑temperature recrystallization. This process avoids aggressive thermal degradation that can impair genistein molecular integrity and biological activity, compared with harsh high‑temperature processing routes that generate higher levels of related‑substance impurities.
HPLC‑Driven Batch‑to‑Batch Standardization — Every production lot is quantified by HPLC for genistein purity, alongside profiling of related isoflavone impurities such as daidzein and glycitein. Multi‑analyte documentation gives formulators full ingredient traceability to support regulatory filing and finished‑product label claims.
Controlled Impurity and Residual Management — Even though genistein from Sophora japonica is non‑soy‑derived, our quality system monitors potential cross‑contact plant allergens. Each batch is tested for residual solvent levels in compliance with ICH Q3C guidelines, minimizing processing‑related contaminants in the final powder.
Heavy‑Metal and Microbiological Compliance — Each lot undergoes ICP‑MS heavy‑metal screening, full microbiological panel testing and critical food‑safety parameter verification before commercial release.
Complete Export Documentation — COA, MSDS, impurity profile certificate, heavy‑metal test report and batch‑traceability records accompany every shipment.
Certificate of Analysis
What Is Genistein
Botanical Source and Biological Composition
Genistein (CAS 446‑72‑0, molecular formula C₁₅H₁₀O₅) is an isoflavone‑class polyphenol naturally accumulated in the fruit of Sophora japonica. As a phytoestrogen, it interacts with human estrogen receptors ERα and ERβ, delivering selective modulatory effects on hormone‑related biological pathways. It also exhibits potent free‑radical‑scavenging antioxidant capacity and well‑documented tyrosine‑kinase‑inhibitory properties. These multi‑mode biological actions underpin its broad use in women‑health nutraceuticals and anti‑aging cosmetic formulations.
Genistein Extract vs. Crude Sophora Japonica Powder
Crude Sophora japonica powder is mechanically milled dried plant material containing genistein alongside large amounts of fibre, polysaccharides and other flavonoids; genistein content varies widely with growing season, harvest time and raw‑material origin. Genistein produced via extraction, chromatography and recrystallization is highly enriched and standardized to ≥98% genistein by HPLC. This consistent high‑purity specification enables precise dose control and reliable batch‑reproducibility for finished dietary‑supplement and cosmetic products.
Production Process
Incoming Sophora japonica fruit raw material is inspected for botanical identity, initial marker‑compound content, heavy‑metal levels and microbiological status prior to manufacturing.
Raw‑Material Pretreatment — Dried Sophora japonica fruit is cleaned, crushed and screened to remove foreign plant fragments and physical contaminants. Botanical identity is confirmed before extraction commences.
Food‑Grade Solvent Extraction — Pretreated plant material undergoes circulating food‑grade solvent extraction under controlled moderate temperature to solubilize isoflavone components, maximizing genistein yield while limiting co‑extraction of unwanted high‑molecular‑weight plant impurities.
Concentration and Crude Enrichment — The extraction liquor is vacuum‑concentrated at low temperature to recover solvent and obtain an enriched crude isoflavone fraction.
Column Chromatography Purification — Crude concentrate is loaded onto chromatographic resin for selective adsorption and elution. This step separates genistein from other co‑extracted flavonoids, sugars and plant‑derived impurities.
Recrystallization for Final Standardization — Chromatography‑purified genistein solution is subjected to controlled recrystallization to achieve target ≥98% HPLC purity. Crystalline solids are isolated by filtration.
Quality Release and Packaging — Dried powder is assayed for genistein content by HPLC, residual solvents, related‑substance profile, heavy metals, moisture and microbiological safety. Qualified material is packed into double‑layer PE inner bags with desiccants, then sealed within light‑proof, moisture‑barrier fibre drums.
Functional Properties & Benefits
Women’s Hormonal‑Balance & Menopausal Wellness
Genistein is widely incorporated into women‑health nutraceutical formulations. Its selective phytoestrogen activity supports formulations targeting menopausal comfort, helping to mitigate hot flashes and mood‑related discomforts associated with declining endogenous estrogen levels. It serves as a plant‑based alternative for finished‑product positioning without synthetic‑hormone‑derived ingredients.
Bone‑Health Support
Genistein modulates bone‑remodelling pathways. Supplement formulations leverage its activity to support maintenance of healthy bone mineral density, making it a key active for age‑related bone‑wellness dietary‑supplement lines for post‑menopausal consumers.
Antioxidant and Cardiovascular Wellness
Powerful free‑radical‑scavenging antioxidant properties enable genistein‑containing products to support cellular defence against oxidative stress. Formulators integrate genistein into antioxidant‑complex and cardiovascular‑support supplements targeting vascular‑endothelial protection and healthy lipid metabolism.
Anti‑Aging and Photoprotective Beauty Applications
In ingestible nutricosmetics and topical skincare, genistein delivers dual antioxidant and phytoestrogen‑related skin benefits. It helps counteract UV‑triggered oxidative damage, supports skin‑matrix homeostasis, and assists in maintaining skin firmness and appearance. Its tyrosine‑kinase‑inhibitory profile makes it a desirable active for mature‑skin and anti‑aging serum, cream and lotion formulations.
Applications
Women’s Health & Menopause‑Support Supplements
Genistein bulk material is supplied for hard capsules, tablets and soft‑gel nutraceutical formats. HPLC‑verified high purity, full impurity profiling and complete regulatory documentation support finished‑product positioning in hormone‑balance and menopausal‑comfort supplement categories.
Bone‑Health Dietary Supplements
Multi‑component bone‑support formulations combine Genistein with calcium, vitamin D, magnesium and complementary botanical actives. Bone‑density maintenance and age‑related skeletal wellness are primary market positioning themes for this supplement segment.
Antioxidant & Cardiovascular Nutraceutical Blends
Genistein is compounded with resveratrol, grape seed extract and other antioxidant ingredients for cellular‑defence and cardiovascular‑wellness finished‑goods. Precise high‑purity powder facilitates uniform blending for tablet compression and capsule filling.
Anti‑Aging Cosmetics & Nutricosmetics
High‑purity genistein serves as an active raw material for topical anti‑aging serums, creams and eye‑care products, as well as for ingestible beauty‑from‑within nutricosmetic formulations focused on mature‑skin care and photodamage protection.
Contact VistaExtract for Genistein Supply
VistaExtract supplies Genistein with HPLC‑validated high‑purity profiles, backed by comprehensive third‑party testing. Flexible order sizes are available from laboratory‑scale samples to full‑container bulk shipments. Custom‑purity grades, particle‑size specifications and full allergen‑cross‑contact‑control documentation can be provided upon request. Reach out directly to our sourcing team for immediate project support.
VistaExtract – Your Strategic Partner for Botanical Ingredients and Functional Foods.
Shipping Method
We offer flexible, reliable shipping options to meet your delivery needs, including:
Air freight & Sea freight
International courier services: FedEx, DHL, PostNL, EMS, UPS
Regional express services: SF Express
We will match the most suitable shipping method according to your order volume, delivery address, and urgency, to ensure your goods reach you safely and on schedule.Our Packaging
We offer a range of professional packaging options tailored to different order sizes:
1kg per aluminum bag
5-10kg per carton
25kg per drum
For products with special transportation requirements, we provide customized, enhanced packaging solutions. Take Deoxyarbutin as an example: as this ingredient may discolor during transit, we use vacuum-sealed packaging to preserve its quality and appearance.
Our Factory
As a professional plant extract supplier, we implement stringent quality control across every single step of our factory's operations:
Raw Material Stage: We exercise strict oversight over the planting of raw materials, as well as the sourcing and purchasing processes
Production Stage: Every detail of the product manufacturing process is standardized and monitored
Final Stage: We also carry out strict checks for the product packaging procedure
This full-chain quality control ensures that every product we deliver meets the highest standards of quality.
